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Target intelligence / Profile preview
Cluster of Differentiation 47 (CD47)
- Target
- CD47
- Molecular classification
- Transmembrane glycoprotein, Receptor
01
Overview
CD47, also known as integrin-associated protein (IAP), is a ubiquitously expressed transmembrane glycoprotein that plays critical roles in cellular communication, immune regulation, and disease pathology. It interacts with SIRPα on macrophages to inhibit phagocytosis, acting as a "don't eat me" signal. It also interacts with thrombospondin 1 (TSP-1) and membrane integrins. Overexpression on tumor cells contributes to immune evasion, making it a target for anti-cancer therapies. CD47 also influences apoptosis, cell proliferation, and migration. Altered expression is implicated in diseases like Gaucher disease and pulmonary fibrosis.
- Other names
- Integrin-associated proteinIAP
02
Mechanism of action
Blocking CD47-SIRPα interaction to promote phagocytosis; inducing tumor cell death through antibody engagement or peptide mimetics
03
Biological functions
Immune evasionApoptosis regulationCell proliferationCell migrationCell adhesionInsulin secretion regulationAngiogenesis
04
Disease associations
CancerGaucher diseasePulmonary fibrosis
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