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Cluster of Differentiation 48 (CD48)

Target: CD48
Molecular classification: Signaling Lymphocyte Activation Molecule family, Immunoglobulin superfamily, Receptor

Overview

CD48, also known as SLAMF2, is a GPI-anchored membrane glycoprotein expressed on most hematopoietic cells. It functions in immune regulation by participating in adhesion and activation pathways for immune cells. It interacts with CD2 and CD244/2B4, modulating cytotoxicity and influencing immune responses. Altered CD48 expression is implicated in cancer, autoimmunity, allergy, and infectious diseases, making it a potential prognostic marker and therapeutic target.

Other names: BLAST-1BCM1MEM-102SLAMF2Signaling Lymphocyte Activation Molecule 2

Mechanism of action

Modulation of immune cell activity through receptor-ligand interactions (e.g., CD2, CD244/2B4)

Biological functions

Immune cell adhesionImmune cell activationModulates cytotoxicityLeukocyte adhesionIntercellular communicationImmune regulation

Disease associations

CancerAutoimmunityAllergyInfectious Diseases

Safety considerations

Potential for immune-related adverse events due to modulation of immune cell activity.Dysregulation may contribute to autoimmune conditions or allergic responses.

Biomarkers

Tumor mutational burden (TMB)Microsatellite instability (MSI)

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