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Target intelligence / Profile preview
Cluster of Differentiation 5 (CD5)
- Target
- CD5
- Molecular classification
- Scavenger Receptor Cysteine-Rich Superfamily, Cell surface glycoprotein, Receptor
01
Overview
CD5 is a lymphoid-specific cell surface glycoprotein and a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Primarily expressed on mature T cells and a subset of B cells (B-1a), it functions as a negative regulator of antigen receptor signaling, playing a crucial role in immune tolerance and T/B cell development and activation. While no universally confirmed ligand exists, CD72 and homophilic binding are potential interactions. It has clinical relevance as a marker for T cells and in diseases involving immune dysregulation.
- Other names
- Lymphocyte antigen T1Leu-1T-cell surface glycoprotein CD5
02
Mechanism of action
Modulation of T-cell receptor (TCR) and B-cell receptor (BCR) signaling through association with intracellular signaling proteins and phosphorylation events.
03
Biological functions
Negative regulation of antigen receptor signalingImmune toleranceT cell activation modulationB cell activation modulationModulation of thymocyte selectionEffector differentiationSurvival
04
Disease associations
AutoimmunityLeukemia (e.g., Chronic Lymphocytic Leukemia, CLL)Viral Infection (e.g., Hepatitis C)Immune dysregulation
05
Safety considerations
Potential for immune suppressionAltered immune responsesPotential impact on regulatory T cell functionPotential impact on Th17 cell development
06
Biomarkers
Expression level in T cellsExpression level in B cellsSoluble CD5 levels in serum
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