Target intelligence / Profile preview

Cluster of Differentiation 5 Antigen (CD5)

Target: CD5
Molecular classification: Type I transmembrane glycoprotein, Scavenger Receptor Cysteine-Rich Superfamily, Immunomodulatory receptor

Overview

CD5 is a 67-kDa type I transmembrane glycoprotein and a member of the scavenger receptor cysteine-rich (SRCR) superfamily. It is primarily expressed on T lymphocytes and a subset of B lymphocytes, acting as an immunomodulatory receptor that negatively regulates antigen-specific receptor signaling. It is used as a diagnostic marker in hematolymphoid tissues and is being investigated as a therapeutic target for CAR-T/CAR-NK therapy in cancers expressing high levels of CD5.

Other names: Leu-1Lyt-1Tp67T1

Mechanism of action

Target for chimeric antigen receptor-modified immune effector therapies (CAR-T, CAR-NK)

Biological functions

Negative regulation of antigen-specific receptor signalingImmunomodulationRegulation of T-cell receptor (TCR) signalingRegulation of B-cell receptor (BCR) signalingRegulation of cell death pathwaysPattern recognition receptor

Disease associations

CancerAutoimmunityInfectionLeukemiaLymphomaChronic lymphocytic leukemia (CLL)Mantle cell lymphoma (MCL)

Safety considerations

Potential for on-target, off-tumor toxicity in CAR-T/CAR-NK therapyComplex immunomodulatory roles may lead to unpredictable effects

Biomarkers

Diagnostic marker for leukemia and lymphoma subtypesPotential biomarker for patient selection in CAR-T/CAR-NK therapy

Beyond the preview

Go deeper on Cluster of Differentiation 5 Antigen (CD5).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Cluster of Differentiation 5 Antigen (CD5).

Explore the full profile