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Cluster of Differentiation 6 (CD6)
- Target
- CD6
- Molecular classification
- Cell surface glycoprotein, Receptor
01
Overview
CD6 is a human cell surface glycoprotein primarily expressed on T lymphocytes, playing a crucial role in T cell activation, proliferation, and adhesion. It interacts with ligands like CD166/ALCAM and CD318/CDCP1, influencing immune synapse stability and signal transduction. Variants in the CD6 gene are associated with autoimmune diseases, and its interaction with ALCAM in cancer is being explored for immunotherapy.
- Other names
- TP120T12FLJ44171
02
Mechanism of action
Modulation of T cell activation and adhesion through interaction with ligands like CD166/ALCAM and CD318/CDCP1.
03
Biological functions
T cell activationT cell proliferationCell adhesionImmunological synapse stabilizationImmune response regulation
04
Disease associations
Autoimmune diseasesMultiple sclerosisCancer
05
Safety considerations
Potential for immune-related adverse events due to T cell modulation.Tumor progression/metastasis
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