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Cluster of Differentiation 7 (CD7)
- Target
- CD7
- Molecular classification
- Transmembrane glycoprotein, Immunoglobulin superfamily, Receptor
01
Overview
CD7 is a transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is primarily expressed on thymocytes, mature T cells, natural killer (NK) cells, as well as early-stage B and myeloid progenitor cells. It plays a role in immune cell development, T-cell activation, and acts as a costimulatory molecule. Abnormal expression patterns are clinically relevant in T-cell Acute Lymphoblastic Leukemia (T-ALL), Mycosis Fungoides/Sezary Syndrome, and Refractory Anemia With Excess Blasts (RAEB).
- Other names
- GP40LEU-9TP41Tp40CD7 molecule
02
Mechanism of action
Antibody ligation leading to T-cell activation and proliferation
03
Biological functions
Immune cell developmentT-cell activationCostimulationCytokine inductionAdhesion enhancementApoptosis
04
Disease associations
T-cell Acute Lymphoblastic Leukemia (T-ALL)Mycosis Fungoides/Sezary SyndromeRefractory Anemia With Excess Blasts (RAEB)Cancer
05
Biomarkers
Expression level in T-ALLAbsence in Mycosis Fungoides/Sezary SyndromeAberrant expression in RAEB
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