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Target intelligence / Profile preview
Cluster of Differentiation 79A (CD79a)
- Target
- CD79a
- Molecular classification
- Receptor, Membrane protein, Immunoglobulin superfamily
01
Overview
CD79a (Igα) is a transmembrane protein essential for B cell development and function. It forms a heterodimer with CD79b (Igβ) to create the functional B-cell receptor (BCR) complex. Upon antigen binding, CD79a initiates downstream signaling cascades through its ITAM motifs. Mutations in CD79A cause agammaglobulinemia. Aberrant expression is associated with some B-cell malignancies, making it a potential therapeutic target.
- Other names
- Igα
02
Mechanism of action
Targeting CD79a for therapeutic intervention in B-cell malignancies may involve blocking BCR signaling, inducing antibody-dependent cellular cytotoxicity (ADCC), or promoting apoptosis of malignant B cells. Specific mechanisms depend on the therapeutic agent used.
03
Biological functions
B cell developmentBCR assemblyBCR signalingImmune responseSignal transduction
04
Disease associations
AgammaglobulinemiaB-cell malignanciesPrimary immunodeficiencyCancer
05
Safety considerations
Potential for B-cell depletion and immunosuppressionRisk of off-target effects on normal B cellsCytokine release syndrome
06
Biomarkers
CD79a expression level as a marker for B-cell lineage and malignancy
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