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Target intelligence / Profile preview
Cluster of Differentiation 8 Beta Chain (CD8β)
- Target
- CD8β
- Molecular classification
- Type I transmembrane protein, Receptor, Immunoglobulin superfamily
01
Overview
The cluster of differentiation 8 beta chain (CD8β) is a type I transmembrane glycoprotein that forms part of the CD8 co-receptor complex, which is essential for T cell-mediated immune responses. The CD8 molecule typically exists as either a heterodimer composed of one alpha (CD8α) and one beta (CD8β) chain or as a homodimer of two alpha chains. It plays an essential role in thymic selection during T cell development ensuring proper maturation into functional CTLs capable of recognizing self-MHC class I molecules presenting foreign peptides.
02
Mechanism of action
Antibodies against CD8 are used for depletion or modulation of cytotoxic T lymphocytes.
03
Biological functions
Co-receptor activityT cell activationMHC-I bindingSignal transductionImmune response
04
Disease associations
CancerInfectionAutoimmune diseasesImmunodeficiency
05
Safety considerations
ImmunosuppressionCytokine release syndromeOff-target effects of CD8-targeted therapies
06
Biomarkers
CD8 expression levels can indicate immune status and response to therapyCD8+ T cell infiltration in tumors as a prognostic marker
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