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Target intelligence / Profile preview
Cluster of Differentiation 86 (CD86)
- Target
- CD86
- Molecular classification
- Immunoglobulin superfamily, Type I transmembrane glycoprotein, Receptor
01
Overview
CD86 (Cluster of Differentiation 86), also known as B7-2, is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is primarily expressed on antigen-presenting cells (APCs) and plays a crucial role in the regulation of T cell activation and immune response modulation by interacting with CD28 (stimulatory) and CTLA4/CD152 (inhibitory) receptors on T lymphocytes.
- Other names
- B7-2Activation B7-2 antigenBU63CTLA-4 counter-receptor B7.2FUN-1Activation antigen D12S364ECluster designation antigen BU63/B70/CD28LG2B7-2/B70/BU63/CTLA-4 counter-receptor/FUN-1/T lymphocyte activation antigen/T-cell costimulatory molecule/T-cell surface glycoprotein ligand
02
Mechanism of action
CD86 interacts with CD28 to provide co-stimulatory signals for T cell activation and with CTLA4 to deliver inhibitory signals, modulating T cell activity.
03
Biological functions
T cell co-stimulationT cell inhibitionImmune response regulationImmunoglobulin class-switchingNF-kappa-B signaling
04
Disease associations
Autoimmune diseasesInflammation
05
Safety considerations
Potential for excessive pro-inflammatory cytokine productionDysregulation can lead to autoimmunity
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