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Target intelligence / Profile preview
Cluster of Differentiation 96 (CD96)
- Target
- CD96
- Molecular classification
- Immunoglobulin superfamily, Type I transmembrane glycoprotein, Receptor
01
Overview
CD96, also known as Tactile, is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. Primarily expressed on NK and T cells, it mediates adhesive interactions with target cells via CD155/PVR. Functioning as an immune checkpoint, CD96 blockade has shown promise in enhancing anti-tumor immunity, particularly when combined with other checkpoint inhibitors.
- Other names
- TACTILET cell activation, increased late expression proteinCell surface antigen tactile
02
Mechanism of action
Blocking CD96 enhances anti-tumor immunity, potentially synergizing with PD‑1 or TIGIT blockade.
03
Biological functions
Cell adhesionImmune responseAntigen presentationImmune checkpointRegulation of NK cell activityRegulation of T cell activity
04
Disease associations
CancerChronic viral infectionsChemoresistance
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