Target intelligence / Profile preview

Cluster of Differentiation Antigen 19 (CD19)

Target: CD19
Molecular classification: Transmembrane protein, Type I transmembrane protein, Receptor, B-cell receptor co-receptor

Overview

CD19 is a transmembrane glycoprotein expressed on B cells from early pre-B cell stage until differentiation into plasma cells. It functions as a co-receptor in the B cell receptor (BCR) complex, playing a crucial role in B cell development, activation, and immune response regulation. Due to its specific expression pattern, it is a valuable diagnostic marker for B-cell malignancies and a prominent target for immunotherapeutic strategies such as monoclonal antibodies, antibody-drug conjugates, and CAR-T cell therapies.

Other names: B-lymphocyte antigen CD19B-cell surface antigen CD19

Mechanism of action

Antibody-mediated cell killing, receptor blockade, CAR-T cell mediated cytotoxicity

Biological functions

B cell developmentB cell activationImmune response regulationSignal transductionB cell survivalB cell proliferationB cell differentiation

Disease associations

LeukemiaLymphomaB-cell malignanciesAutoimmune diseases (potential)

Safety considerations

Cytokine release syndrome (CRS)Neurotoxicity (ICANS)B cell aplasiaTumor lysis syndrome

Interacting drugs

Monoclonal antibodies (e.g., blinatumomab)

2 more in the full profile.

Biomarkers

CD19 expression level in B cells (diagnostic and prognostic)Minimal residual disease (MRD) assessment post-therapy

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