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Target intelligence / Profile preview
Clusterin (CLU)
- Target
- CLU
- Molecular classification
- Glycoprotein, Chaperone
01
Overview
Clusterin (CLU), also known as Apolipoprotein J, is a multifunctional, secreted glycoprotein that acts primarily as an extracellular molecular chaperone. It is widely expressed and found in various body fluids. Clusterin binds misfolded proteins, inhibits apoptosis, and prevents complement-mediated cell lysis. Alterations in clusterin expression are implicated in numerous diseases, including Alzheimer's disease and cancer.
- Other names
- Apolipoprotein JApoJAging-associated gene 4 protein
02
Mechanism of action
Acts as an ATP-independent molecular chaperone for misfolded proteins; inhibits apoptosis by interacting with BAX on mitochondria and modulating survival pathways; prevents complement-mediated cell lysis by binding terminal complement complexes.
03
Biological functions
Molecular chaperone activityAnti-apoptosisComplement inhibitionLipid transportMembrane recyclingHormone transportMatrix metalloprotease inhibitionPhagocyte recruitmentAngiogenesis promotion
04
Disease associations
Alzheimer's diseaseCancerMyocardial infarctionRenal tubular damageAutoimmunityRetinitis pigmentosaInfectionOrgan regeneration
05
Safety considerations
Overexpression confers resistance to apoptosis induced by therapy in cancer.May promote tumor progression/survival.
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