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Target intelligence / Profile preview
Clusterin-associated protein 1 (CLUAP1)
- Target
- CLUAP1
- Molecular classification
- Other (Cilia/flagella assembly protein, Intraflagellar transport component)
01
Overview
Clusterin-associated protein 1 (CLUAP1) is a protein required for cilia biogenesis and is a key part of the intraflagellar transport complex B (IFT-B), essential for assembly and maintenance of primary cilia. It also acts as an important regulator of hedgehog signaling, which is critical for development. Mutations in CLUAP1 are associated with ciliopathies, including Leber plus disease and Bardet-Biedl syndrome, and can have broader impacts on organelle function and development. CLUAP1 participates in protein binding within the ciliary tip and cell projections, with tissue expression in various organs, notably those relying on cilia for function.
- Other names
- KIAA0643FLJ13297FAP22CFAP22IFT38QilinClusterin associated protein 1Cilia and flagella associated protein 22Flagellar associated protein 22Qilin-like proteinHomolog (Chlamydomonas)
02
Biological functions
Cilia biogenesisIntraflagellar transport (IFT-B complex)Regulation of hedgehog signalingProtein binding
03
Disease associations
Ciliopathies (e.g., Bardet-Biedl syndrome)Leber plus diseaseAniridia 1Other cilia-related disorders
04
Safety considerations
No therapeutic agents or direct manipulation; disruption may impair cilia function and signaling
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