CMRF35-like molecule 1 receptor (CD300LF)

CMRF35-like molecule 1 receptor (CD300LF) is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily, primarily expressed on myeloid cells such as mast cells, monocytes, macrophages, and some dendritic cells[3][4]. It acts as an inhibitory immune receptor by transmitting signals through cytoplasmic ITIM motifs, thus downregulating inflammatory responses and preventing overactivation of immune cells. CD300LF is involved in the recognition and phagocytosis of apoptotic cells via binding to phospholipids like phosphatidylserine. In mice, CD300LF is the principal cellular receptor for murine norovirus, mediating viral entry by direct protein–protein interaction, and this process requires specific extracellular domains of CD300LF[1][2]. The human ortholog likely participates in similar regulatory functions but is not documented as a viral receptor. There are currently no approved therapeutic agents that directly target CD300LF; its role is principally of preclinical and immunological interest.

Other names

CD300LFCD300FCLM1IGSF13IREM1NKIRLMIR3CLM-1IREM-1IgSF13CD300 antigen-like family member Fimmune receptor expressed on myeloid cells 1immunoglobulin superfamily member 13NK inhibitory receptorinhibitory receptor IREM1

Inhibitory signaling via immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain, leading to negative regulation of immune cell activation; Serves as a cell entry receptor for murine norovirus (MNoV) via direct interaction with viral capsid proteins[1][2]; Binds phospholipids (e.g., phosphatidylserine, phosphatidylcholine), contributing to recognition of apoptotic cells and modulation of phagocytosis[1]