CMT1A duplicated region transcript 7 (CDRT7)

CMT1A duplicated region transcript 7 (CDRT7) is a long intergenic non-protein coding RNA (lincRNA) located on chromosome 17p12, within the 1.4-Mb CMT1A/HNPP duplication/deletion region[1][3][4][5][6]. It consists of three exons and spans 767 bp[1]. It does not encode a protein, with multiple assessments (CPAT, PRIDE, PhyloCSF) indicating non-coding potential[1]. While best characterized as a genomic element in the context of structural variation regions involving peripheral neuropathies (notably Charcot-Marie-Tooth disease type 1A and hereditary neuropathy with liability to pressure palsy), there is no established direct therapeutic targeting or clear biological function, though some databases list a potential association with Autism Spectrum Disorder based on genomic studies[4][5]. No interacting drugs, mechanisms of action, or biomarker roles are currently described for this lincRNA.

Other names

LINC00025NCRNA00025non-protein coding RNA 25long intergenic non-protein coding RNA 25CDRT7-001ENST00000568256.1OTTHUMT00000130381.1NONHSAT145786NR_033371ENSG00000259944OTTHUMG00000058961.1