Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
cMyc oncogene (MYC)
- Target
- MYC
- Molecular classification
- Transcription factor, bHLH-LZ transcription factor
01
Overview
The cMyc oncogene (MYC) is a proto-oncogene encoding a nuclear phosphoprotein that functions as a transcription factor. It regulates cell cycle progression, cellular growth, metabolism, apoptosis, differentiation, self-renewal, and protein synthesis. Overexpression of MYC is implicated in a majority of human cancers, making it a significant therapeutic target. However, its structure poses challenges for drug development.
- Other names
- c-MycMYCProto-oncogene c-Myc
02
Mechanism of action
Inhibition of mRNA expression/translation, disruption of dimerization with Max, induction of premature degradation, blocking DNA binding activity
03
Biological functions
Cell cycle progressionCellular growthMetabolismApoptosisDifferentiationSelf-renewalProtein synthesisGene expression regulation
04
Disease associations
Cancer
05
Safety considerations
Essential for embryonic development - knockout is embryonic lethalRequired for mature cell survival/growth/differentiation in adultsLack of defined pockets for small molecule binding making it difficult to target with conventional drugs
Beyond the preview
Go deeper on cMyc oncogene (MYC).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on cMyc oncogene (MYC).