CoA biosynthesis pathway

The *CoA biosynthesis pathway* comprises the set of enzymatic reactions responsible for producing **coenzyme A** from pantothenic acid (vitamin B5), cysteine, and ATP in all living organisms[1][3][6][9]. CoA is essential for central metabolism, particularly in the synthesis and oxidation of fatty acids, the citric acid cycle, and the regulation of multiple cellular functions. The pathway involves several enzymes, including pantothenate kinase (PanK), phosphopantothenoylcysteine synthetase (PPCS), phosphopantothenoylcysteine decarboxylase (PPCDC), phosphopantetheine adenylyltransferase (PPAT), and dephospho-CoA kinase (DPCK). Each enzyme is a potential antifungal or antibacterial drug target, especially in pathogens such as *Mycobacterium tuberculosis* and *Plasmodium* spp., but the pathway as a whole is not a single drug target[2][6][7]. Rather, it is a metabolic process comprising individual enzymes, each of which may serve as a potential therapeutic target due to their essential function in organism viability and disease[4][6][7][9]. **Note:** If structured data is needed for a specific enzyme (e.g., “pantothenate kinase”, “CoaBC”, “CoA synthase”), please provide the enzyme's name for detailed target information. The provided information covers the *biosynthetic pathway* as a concept, not a single molecular target.

Other names

Coenzyme A biosynthesis pathwayPantothenate and coenzyme A biosynthesis pathwayCoA pathway