Target intelligence / Profile preview

Coagulation

Molecular classification
Biological process, Cascade
01

Overview

Coagulation, also known as blood clotting, is a complex physiological process by which blood changes from a liquid to a gel, forming a blood clot. This process is essential for hemostasis—the cessation of bleeding following vascular injury—and involves the activation, adhesion, and aggregation of platelets along with the deposition and maturation of fibrin. Coagulation prevents excessive bleeding when vessels are damaged but can also lead to pathological conditions if dysregulated.

Other names
Blood clottingHemostasis
02

Mechanism of action

Varies depending on the drug; examples include inhibiting specific coagulation factors (e.g., thrombin, factor Xa), inhibiting platelet aggregation, or enhancing fibrinolysis.

03

Biological functions

Stops bleeding (hemostasis) after vessel injuryForms clots that seal wounds and allow tissue repair
04

Disease associations

Hemorrhagic conditionsThrombosisHemophiliaStrokeDeep vein thrombosis
05

Safety considerations

BleedingThrombosisDrug interactionsAdverse reactions to anticoagulants and antiplatelet drugs
06

Interacting drugs

Anticoagulants (e.g., Warfarin, Heparin, Direct Oral Anticoagulants)

1 more in the full profile.

07

Biomarkers

Prothrombin time (PT)Activated partial thromboplastin time (aPTT)International normalized ratio (INR)D-dimer

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