Coagulation factor complex on phosphatidylserine surface

During hemostasis, coagulation factors assemble into enzymatically active complexes (notably the prothrombinase complex: factor Xa and Va) on surfaces exposing phosphatidylserine, particularly activated platelet membranes[1][2][3][4]. Phosphatidylserine provides a negatively charged surface that accelerates thrombin generation by up to 150,000-fold, making it critical for efficient clot formation[2][3]. This membrane-anchored assembly is essential for proper blood coagulation and is implicated in a range of pathologies: excess activity can contribute to thrombosis, while deficiency or aberrant exposure (as seen in rare disorders such as Scott syndrome, or in certain autoimmune and infectious states) leads to bleeding or inappropriate coagulation[2][4]. The therapeutic targeting of these complexes typically involves inhibitors of factor Xa or thrombin, or the interference with phosphatidylserine binding domains, and is a key strategy in modern anticoagulation therapy[1][3]. Note: - This entry combines several individual protein targets (coagulation factors) and a lipid cofactor (phosphatidylserine), describing a multi-component, membrane-associated enzymatic complex rather than a single molecule or receptor. - Because “Coagulation Factors on Phosphatidylserine Surface” refers to a functional assembly/process and not a singular, uniquely-named molecule, the query is *partially incorrect* in the context of standard molecular target nomenclature. The provided information reflects this specificity.

Other names

Coagulation factor complexesProthrombinase complex on phosphatidylserineBlood clotting factors on activated platelet membrane

Inhibition of assembly or activity of coagulation complexes (e.g., prothrombinase) on phosphatidylserine surface; competitive binding to phosphatidylserine; direct enzyme inhibition (factor Xa, thrombin)