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Target intelligence / Profile preview
Coagulation Factor IXa (FIXa)
- Target
- FIXa
- Molecular classification
- Serine protease, Enzyme, Peptidase family S1, Vitamin K-dependent protein
01
Overview
Coagulation factor IXa is the activated form of coagulation factor IX, a vitamin K-dependent serine protease essential for blood clotting. It catalyzes the activation of factor X to Xa, a critical step in thrombin generation and fibrin clot formation. Deficiency leads to hemophilia B, treatable with Factor IX replacement therapy.
- Other names
- Factor IXaF9FIXHEMBP19PTCTHPH8Christmas Factor
02
Mechanism of action
Replacement therapy: Provides functional Factor IXa to facilitate blood clotting.
03
Biological functions
Blood coagulationActivation of Factor XHemostasis
04
Disease associations
Hemophilia BBleeding disorders
05
Safety considerations
Thromboembolic events (rare)Development of inhibitors (antibodies against Factor IX)Allergic reactions
06
Interacting drugs
Recombinant Factor IX
1 more in the full profile.
07
Biomarkers
Factor IX activity levelsFactor IX antigen levels
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