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Target intelligence / Profile preview
Coagulation Factor Va (FVa)
- Target
- FVa
- Molecular classification
- Cofactor, Coagulation Factor
01
Overview
Coagulation factor Va (FVa) is the activated form of coagulation factor V and a crucial cofactor in the blood coagulation cascade. It forms a complex with factor Xa (FXa) on phospholipid surfaces to efficiently convert prothrombin to thrombin, a key step in hemostasis. Its activity is regulated by activated protein C (APC). Deficiency leads to bleeding disorders, while resistance to APC-mediated inactivation (e.g., Factor V Leiden mutation) increases the risk of thrombosis.
- Other names
- Activated Factor VFactor Va
02
Mechanism of action
FVa acts as a cofactor for FXa in the prothrombinase complex, accelerating the conversion of prothrombin to thrombin. Drugs targeting FVa can inhibit its activity or regulate its activation/inactivation.
03
Biological functions
HemostasisBlood coagulationProthrombinase complex formationThrombin generation
04
Disease associations
Bleeding disorders (deficiency)Thrombosis (Factor V Leiden)HemophiliaThrombophilia
05
Safety considerations
Bleeding risk (inhibition of FVa)Thrombotic risk (Factor V Leiden, APC resistance)Development of inhibitors against Factor V
06
Interacting drugs
Warfarin
3 more in the full profile.
07
Biomarkers
Factor V activity levelsFactor V Leiden mutationAPC resistanceProthrombin time (PT)Activated partial thromboplastin time (aPTT)
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