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Target intelligence / Profile preview
Coagulation Factor VIIIa (FVIIIa)
- Target
- FVIIIa
- Molecular classification
- Cofactor, Glycoprotein
01
Overview
Coagulation factor VIIIa is the activated form of coagulation factor VIII, a critical non-enzymatic plasma protein essential for normal blood clotting. It acts as a cofactor in the intrinsic pathway of the coagulation cascade, specifically facilitating the activation of factor X by factor IXa in the presence of calcium ions and phospholipids on activated platelet surfaces. Deficiency or dysfunction leads to hemophilia A. High levels are associated with increased risk for deep vein thrombosis and pulmonary embolism.
- Other names
- Activated Factor VIIIF8aAHF (antihemophilic factor) activated
02
Mechanism of action
Replacement therapy with FVIII concentrates; bispecific antibodies mimic FVIIIa cofactor function; gene therapy aims to restore endogenous FVIII production.
03
Biological functions
Blood coagulationActivation of Factor XFormation of intrinsic tenase complex
04
Disease associations
Hemophilia AThrombosisPulmonary embolism
05
Safety considerations
Inhibitor development (antibodies against FVIII in replacement therapy)Thrombotic events (with high FVIII levels)Viral transmission (with plasma-derived products, although risk is minimized with current purification methods)Anaphylaxis/allergic reactions to FVIII products
06
Interacting drugs
Recombinant Factor VIII
3 more in the full profile.
07
Biomarkers
Factor VIII activity levelsFactor VIII antigen levelsInhibitor assays (for detecting antibodies against FVIII)Genetic testing for F8 mutations
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