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Target intelligence / Profile preview
Coagulation Factor X (activated) (FXa)
- Target
- FXa
- Molecular classification
- Serine endopeptidase, Protease, Enzyme
01
Overview
Coagulation factor X, also known as Stuart factor, is a vitamin K-dependent serine endopeptidase synthesized in the liver. Upon activation by either the intrinsic (FVIIIa-FIXa complex) or extrinsic (TF-FVIIa complex) pathways, it becomes activated factor X (FXa), a central enzyme in the coagulation cascade. FXa catalyzes the conversion of prothrombin to thrombin within the prothrombinase complex, which is critical for fibrin formation and stable clot development. Beyond coagulation, recent studies highlight roles in inflammation/fibrosis through PAR signaling pathways.
- Other names
- Factor XaActivated Factor XStuart factor (activated)
02
Mechanism of action
Direct inhibition of FXa enzymatic activity
03
Biological functions
Blood coagulationHemostasisActivation of prothrombin to thrombinProteolysisInflammation (PAR signaling)Fibrosis (PAR signaling)
04
Disease associations
ThrombosisBleeding disordersAcute coronary syndromeVenous thromboembolismInflammationFibrosis
05
Safety considerations
Bleeding riskThrombocytopenia
06
Interacting drugs
Rivaroxaban
1 more in the full profile.
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