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Target intelligence / Profile preview
Coagulation Factor XI Messenger RNA (F11 mRNA)
- Target
- F11 mRNA
- Molecular classification
- RNA, Messenger RNA
01
Overview
Coagulation factor XI messenger RNA (F11 mRNA) is the transcript produced from the F11 gene, which encodes coagulation factor XI (FXI), a key protein in the intrinsic pathway of blood coagulation. FXI plays an essential role in blood clotting by activating factor IX after its own activation, leading to downstream activation of factors that ultimately generate thrombin and fibrin clots. Because FXI plays a more prominent role in pathological thrombosis than physiological hemostasis, it is considered an attractive target for anticoagulant therapies aiming to reduce thrombotic risk with minimal impact on normal bleeding control.
- Other names
- FXI mRNA
02
Mechanism of action
Antisense oligonucleotide therapies could target F11 mRNA to reduce FXI protein levels.
03
Biological functions
Blood coagulationRegulation of hemostasisActivation of factor IX
04
Disease associations
Factor XI deficiencyThrombosis
05
Safety considerations
Potential for off-target effects with mRNA-targeted therapies.Risk of bleeding complications if FXI levels are excessively reduced.
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