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Coagulation Factor XII (F12)
- Target
- F12
- Molecular classification
- Serine Protease, Zymogen, Glycoprotein
01
Overview
Coagulation factor XII (F12), also known as Hageman factor, is a plasma glycoprotein that initiates the intrinsic pathway of blood coagulation. It is synthesized in the liver and circulates as an inactive zymogen. Upon contact with negatively charged surfaces, it autoactivates to factor XIIa (FXIIa), triggering a cascade leading to clot formation. FXIIa also activates the kallikrein-kinin system and complement system, contributing to inflammation. Deficiency in Factor XII does not typically cause bleeding disorders, but it plays a role in pathological thrombosis, making it a therapeutic target for antithrombotic agents with reduced bleeding risk.
- Other names
- Hageman factor
02
Mechanism of action
Inhibition of Factor XII activation or activity
03
Biological functions
Initiation of intrinsic coagulation pathwayKallikrein-kinin system activationComplement system activationHemostasis
04
Disease associations
ThrombosisHereditary angioedemaInflammation
05
Safety considerations
Potential for off-target effectsDevelopment of inhibitors
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