Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Coagulation Factor XIII A Subunit (FXIII-A)
- Target
- FXIII-A
- Molecular classification
- Enzyme, Transglutaminase
01
Overview
Coagulation factor XIII A subunit (FXIII-A) is a crucial enzyme in the blood coagulation cascade, responsible for stabilizing fibrin clots. It is a transglutaminase that catalyzes the formation of covalent cross-links between glutamine and lysine residues in fibrin molecules, increasing clot strength, rigidity, and resistance to fibrinolysis. Deficiency leads to bleeding diathesis.
- Other names
- Fibrin-stabilizing factor subunit AFactor XIII A chain
02
Mechanism of action
Catalyzes the formation of covalent cross-links between glutamine and lysine residues in fibrin, stabilizing the clot.
03
Biological functions
Blood coagulationFibrin clot stabilizationCross-linking of fibrinWound healing
04
Disease associations
Bleeding disordersThrombosisImpaired wound healing
05
Safety considerations
Inhibition may lead to bleeding complicationsTherapeutic FXIII-A administration may rarely cause allergic reactions or thrombosis
06
Biomarkers
FXIII-A plasma levels (for deficiency diagnosis)
Beyond the preview
Go deeper on Coagulation Factor XIII A Subunit (FXIII-A).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Coagulation Factor XIII A Subunit (FXIII-A).