Coatomer protein complex subunit beta 2 (COPB2)

Coatomer protein complex subunit beta 2 (COPB2) is an essential component of the cytosolic coatomer protein complex (COPI complex), which is required for the formation of non-clathrin-coated vesicles involved in Golgi budding and vesicular trafficking. It is required for retrograde Golgi-to-ER transport of dilysine-tagged proteins, and plays a key role in the structural maintenance of the Golgi apparatus. COPB2 acts as a selective binding (RACK) protein for protein kinase C, epsilon type, and its loss of function causes developmental syndromes involving microcephaly and osteoporosis. COPB2 is also reported to have a role as an oncogene in several cancers[1][2][3][4][5]. Notes: - Is_target is set to false because COPB2 acts as a structural/trafficking molecule rather than a receptor, transporter, enzyme, or conventional therapeutically targeted receptor. There are no known drugs or targeted therapeutic interventions reported for COPB2 as of current data. - Fields like interacting_drugs, mechanism_of_action, biomarkers, and safety_concerns are null due to the lack of specific small molecules, targeted drugs, or related clinical targeting information in current literature[1][2][3][4][5]. - COPB2 is implicated in disease mainly through genetic loss-of-function or aberrant expression, not as a direct drug target.

Other names

Coatomer subunit beta'beta'-COPbetaprime-COPBeta'-coat proteinp102COPI coat complex subunit beta 2MCPH19OPDDbeta prime subunitcoatomer protein complex subunit beta primecoatomer protein complex, subunit beta 2 (beta prime)