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Target intelligence / Profile preview
Coatomer protein complex subunit zeta-2 (COPZ2)
- Target
- COPZ2
- Molecular classification
- Other, Coatomer complex subunit, Vesicular transport machinery
01
Overview
Coatomer protein complex subunit zeta-2 (COPZ2) is a small subunit of the coatomer protein complex (COPI), which contains seven subunits and is essential for the formation and function of COPI-type, non-clathrin-coated vesicles. COPI vesicles play a central role in retrograde transport from the Golgi back to the endoplasmic reticulum, specifically transporting dilysine-tagged proteins. In normal cellular physiology, COPZ2 is functionally redundant with its paralog COPZ1, allowing cells to tolerate loss or inhibition of one paralog. However, in certain cancers, COPZ2 is frequently silenced by epigenetic mechanisms, forcing tumor cells to depend solely on COPZ1 for maintaining Golgi integrity and vesicle trafficking. Aberrant silencing of COPZ2 can disrupt intracellular transport and contribute to tumorigenesis. Its altered expression and silencing have made it a potential component of prognostic gene signatures in some cancers.
- Other names
- ZETA2-COPCOPI coat complex subunit zeta 2COPZ2_HUMAN
02
Biological functions
Retrograde Golgi-to-ER transportVesicle formation and traffickingRegulation of biosynthetic protein transport
03
Disease associations
Cancer (altered expression/silencing in several tumor types, including bladder and endometrial cancer)Developmental and epileptic encephalopathyPenis squamous cell carcinoma
04
Biomarkers
Prognostic gene signature component in bladder cancer
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