COBW domain containing 7 pseudogene

COBW domain containing 7 pseudogene (Ensembl: ENSG00000225394, also known as LOC100419812, AC106883.1) is classified as a pseudogene in humans and is not considered a functional gene nor a therapeutic target[1][2][3]. The name derives from sequence similarity to genes encoding the CobW domain—a domain involved in metal chaperoning and GTPase activity in prokaryotic species and some Eukaryote (non-human) genes[5][6]. Unlike its protein-coding paralogs or homologs, which may play roles in metal homeostasis and cobalamin (vitamin B12) biosynthesis in other organisms[5][6], this pseudogene does not have known biological functions, roles in disease, or relevance as a drug-interacting molecule, biomarker, or safety concern in humans[1][2][3]. Since it is a *pseudogene*, it is not used as a receptor, enzyme, transporter, or other classic therapeutic target molecule. The presence of “domain containing” in the name refers to a homologous region, but the gene itself is defunct with no evidence of protein-coding activity or biological relevance in human cell biology. Notes: - There is nothing fundamentally incorrect in the naming conventions, but **as a pseudogene, it is not a valid therapeutic target** and contains no known coding function or drug relevance[1][2][3]. - “COBW domain containing 7 pseudogene” should not be mistaken for active CobW domain-containing proteins (such as ZNG1F/ZNG1C)[7]; those are protein-coding and may have molecular or therapeutic relevance in other contexts[5][7]. Summary rationale: This entry describes a human pseudogene with *no protein product, no known biological function or disease involvement, and no evidence as a drug target*; hence “is_target” is false and “is_incorrect” is true (for the purposes of structured drug target databases)[1][2][3].

Other names

COBW domain containing pseudogeneCOBW domain containing 7 pseudogeneLOC100419812AC106883.1[2]