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Target intelligence / Profile preview
Cocaine esterase (CocE)
- Target
- CocE
- Molecular classification
- Enzyme, Hydrolase, Carboxylesterase
01
Overview
Cocaine esterase (CocE) is a bacterial enzyme that catalyzes the hydrolysis of cocaine into ecgonine methyl ester and benzoic acid. It is recognized as the most efficient natural catalyst for cocaine degradation discovered to date. The enzyme was originally identified in soil bacteria, such as *Rhodococcus* sp. strain MB1, which can use cocaine as their sole source of carbon and nitrogen. Engineered forms, like TNX-1300, are being developed for the treatment of acute cocaine intoxication.
- Other names
- human carboxylesterase 2 (hCE2)cocaine benzoylhydrolase
02
Mechanism of action
Hydrolyzes cocaine into ecgonine methyl ester and benzoic acid
03
Biological functions
Cocaine catabolismHydrolysis of estersDrug metabolism
04
Disease associations
Cocaine intoxication
05
Safety considerations
Wild-type CocE has limited stability at human body temperaturePotential immunogenicity of engineered CocE variants
06
Interacting drugs
Cocaine
2 more in the full profile.
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