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Target intelligence / Profile preview
Cockroach Allergen Proteins (N/A)
- Target
- N/A
- Molecular classification
- Protein, Allergen, Lipid-binding protein, Aspartic proteinase-like protein, Hemocyanin, Serine protease, Chitinase, Vitellogenin
01
Overview
Cockroach allergen proteins are a group of molecules found in cockroaches (e.g., *Blattella germanica*) that trigger allergic immune reactions. Major allergens include Bla g 1 (a lipid-binding protein), Bla g 2 (an aspartic proteinase-like protein), and others. Exposure to these allergens is a significant risk factor for asthma and other respiratory diseases. Some cockroach extracts also contain serine proteases that can activate PAR2, contributing to airway inflammation.
- Other names
- Bla g 1Bla g 2Bla g 3Bla g 4Bla g 5Bla g 6Bla g 7Bla g 8Bla g 12ChitinaseVitellogenin
02
Mechanism of action
N/A
03
Biological functions
AllergenicityIgE bindingT cell activationLipid bindingPossible digestive functionPAR2 activation (serine proteases)
04
Disease associations
AsthmaAllergyRespiratory diseaseAirway inflammation
05
Safety considerations
Allergic reactionsAsthma exacerbationAirway inflammation
06
Interacting drugs
PAR2 inhibitors
07
Biomarkers
IgE levels specific to cockroach allergens (e.g., Bla g 1, Bla g 2)
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