Codanin-1 (CDAN1)

**Codanin-1 (CDAN1)** is an essential and ubiquitously expressed protein involved in the maintenance of nuclear structure, chromatin assembly, and the cell cycle[3][4]. It interacts with histone chaperones ASF1A and ASF1B and is implicated in chromatin condensation by sequestering histone chaperones, thereby impacting nucleosome formation and downstream gene expression[1][2]. Mutations in CDAN1 cause congenital dyserythropoietic anemia type I, leading to defective red blood cell production[3]. While it has a central role in basic cell biology and erythropoiesis, it is not an established therapeutic target, and no drug interactions or established biomarker roles have been reported[1][3][4].

Other names

Codanin-1CDAN1UNQ664/PRO1295CDA-ICDAICDA1CDAN1ADLTPRO1295congenital dyserythropoietic anemia type I proteindiscs lost homolog