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Cofilin-2 (CFL2)
- Target
- CFL2
- Molecular classification
- Actin-binding protein, Cytoskeletal regulator, ADF/cofilin family protein
01
Overview
Cofilin-2 (CFL2) is a skeletal muscle-specific isoform of the actin-depolymerizing factor (ADF)/cofilin family that is essential for regulating actin filament turnover and sarcomere organization in striated muscle[1][3][5]. It binds both G-actin (monomeric) and F-actin (filamentous) in a 1:1 ratio and modulates actin polymerization and depolymerization in a pH-dependent manner[1][3]. CFL2 plays a critical role in maintaining muscle fiber structure by controlling the length of thin filaments and promoting myoblast differentiation[2][5]. Mutations in CFL2 cause nemaline myopathy type 7, characterized by abnormal actin filament accumulation and muscle weakness[1][2][3][5]. While essential for muscle health, CFL2 is not a direct drug target, and there are currently no therapeutic agents modulating its activity[1][3][5].
- Other names
- CFL2Cofilin-2Cofilin, muscle isoformNemaline myopathy type 7NEM7cofilin 2 (muscle)Cofilin, muscle
02
Mechanism of action
Not applicable
03
Biological functions
Regulation of actin-filament dynamicsActin depolymerization and polymerizationMyoblast proliferation and differentiationMyofibril maintenanceSarcomere structure and function
04
Disease associations
Nemaline myopathyMuscle development disorderMyofibrillar myopathy, progressive muscle weakness
05
Safety considerations
Mutations in CFL2 result in progressive muscle pathology (e.g., nemaline myopathy, sarcomeric disruption)Deficiency or dysfunction leads to actin filament accumulation and muscle weaknessTherapeutic challenge: No available targeted therapies; manipulation may affect actin dynamics in skeletal and cardiac muscle, posing risk of adverse effects
06
Biomarkers
Cofilin-2 gene mutationsCofilin-2 protein expression levels
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