Cognitive self-regulation of fear of recurrence (None established)

Cognitive self-regulation of fear of recurrence refers to the set of psychological processes by which individuals—most commonly cancer survivors—manage their emotional responses, thoughts, and behaviors related to the possibility that their disease may return or progress. This is not a molecular target such as a receptor, enzyme, transporter, or gene product; rather it is a multidimensional psychological construct encompassing worry about health status, hypervigilance toward bodily symptoms, intrusive thoughts about illness returning, and associated behavioral changes like excessive checking or avoidance. The concept draws on models such as Leventhal’s self-regulatory model and has been operationalized in research through tools like the FCR7 scale. High levels can lead to significant distress and functional impairment but can be addressed through evidence-based psychotherapies including cognitive behavioral therapy (CBT) and acceptance-and commitment therapy (ACT). There are no drugs targeting this "molecule/receptor," nor are there biological biomarkers for its presence—it is assessed using patient-reported outcome measures. In summary: Cognitive self-regulation of fear of recurrence is not a therapeutic molecular target, but rather describes an important area within psycho-oncology focused on helping patients adaptively manage fears related to disease return after treatment.

Other names

Fear of cancer recurrence (FCR)Fear of recurrenceCognitive regulation of FCRSelf-regulation in cancer survivorship (contextual)

Not applicable for drugs. For psychological interventions: Cognitive restructuring to reduce maladaptive thoughts about recurrence; Behavioral techniques to manage avoidance or reassurance-seeking behaviors; Acceptance-based strategies to help patients live with uncertainty.