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Cohesin subunit SA-1 (SA1)
- Target
- SA1
- Molecular classification
- Other (structural chromosome protein; cohesin complex component)
01
Overview
Cohesin subunit SA-1 (encoded by the STAG1 gene, also known as Stromal antigen 1) is a key component of the cohesin complex, which is essential for sister chromatid cohesion, homologous recombination, and chromosome architecture via DNA looping. The cohesin complex is composed of SMC1, SMC3, RAD21, and either SA-1 or SA-2 in somatic cells. SA-1 stabilizes the complex via RAD21 interaction; its roles include regulation of cohesion loading and release, and telomere cohesion. Disruption of STAG1 function leads to severe developmental defects and is implicated in diseases including certain cancers and chromosomal disorders due to its pivotal role in genome integrity.
- Other names
- STAG1SA1Cohesin subunit SA-1
02
Mechanism of action
null
03
Biological functions
Sister chromatid cohesionDNA loopingHomologous recombinationCell cycle regulationRegulation of gene expression
04
Disease associations
Cancer (mutations associated with oncogenesis and chromosomal instability)Developmental disorders (mutations are lethal in murine embryogenesis)Other (chromosome mis-segregation, cohesinopathies)
05
Safety considerations
Potential embryonic lethality if completely inactivatedChromosome mis-segregation and aneuploidy risk
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