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Target intelligence / Profile preview
Coiled-coil alpha-helical rod protein 1 (CCHCR1)
- Target
- CCHCR1
- Molecular classification
- Other (structural/regulatory protein; not a receptor, enzyme, transcription factor, transporter, ion channel, or histone modifier)
01
Overview
Coiled-coil alpha-helical rod protein 1 (CCHCR1) is a structural protein composed primarily of alpha-helices and coiled-coil domains, encoded by the CCHCR1 gene on human chromosome 6p21.33. CCHCR1 localizes to P-bodies—sites of mRNA metabolism—and is implicated in regulating keratinocyte proliferation and differentiation, potentially functioning as a negative regulator of keratinocyte growth, with relevance in both normal epithelial biology and skin disease. CCHCR1 has notable genetic polymorphisms associated with susceptibility to psoriasis and expression changes in multiple sclerosis and cancers such as cervical carcinoma, sometimes interacting with viral proteins like HPV E2. Although its function is incompletely characterized, it is recognized as a potential marker for proliferative disorders, especially in the skin, but is not considered a classical drug target or receptor.
- Other names
- CCHCR1C6orf18HCRPg8SBPStAR-binding proteinPutative gene 8 proteinAlpha-helical coiled-coil rod protein
02
Biological functions
Regulation of keratinocyte proliferation or differentiationRegulation of mRNA metabolism and stability (through localization to P-bodies)Possible role in steroidogenesis and tissue-specific gene transcriptionCell cycle regulation (G1/S transition)Negative regulation of keratinocyte proliferation
03
Disease associations
Psoriasis (susceptibility and pathogenesis)Multiple sclerosis (genetic associations)Cervical carcinoma/cancer (expression changes, interaction with HPV E2 protein)COVID-19 (genomic association studies)Cutaneous squamous cell carcinoma (expression changes)
04
Biomarkers
Overexpression in psoriatic skin lesionsExpression changes in early cervical neoplasia and squamous cell carcinomaDifferential expression in cutaneous cancer tissue
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