Coiled-coil and C2 domain-containing protein 1A (CC2D1A)

Coiled-coil and C2 domain-containing protein 1A (CC2D1A) is a highly conserved protein encoded by the CC2D1A gene. It functions as a transcriptional repressor, originally identified for repressing the serotonin receptor 1A gene in neurons. CC2D1A also acts as a scaffold protein, anchoring components of the PI3K/Akt pathway and influencing signal transduction and cell survival pathways. In cancer biology, elevated CC2D1A expression correlates with poor prognosis and resistance to chemotherapy in ovarian cancer, mechanistically contributing to survival signaling and reduced apoptosis. Additionally, inherited mutations in CC2D1A cause autosomal recessive intellectual disability, consistent with its neuronal roles[1][2][3].

Other names

Freud-1CCM1Coiled-coil and C2 domain containing 1AC2 domain-containing protein 1A

Chemoresistance promotion through modulation of apoptosis and survival pathways, potentially via NFκB and Akt pathway scaffolding[1][2] Transcriptional repression of the serotonin receptor 1A gene in neuronal cells[3]