Coiled-coil and C2 domain-containing protein 1B (CC2D1B)

Coiled-coil and C2 domain-containing protein 1B (CC2D1B) is a protein found in myelinating glial cells of the central and peripheral nervous system (including Schwann cells and oligodendrocytes). It contains four DM14 domains that mediate interaction with the ESCRT-III endosomal sorting machinery (notably CHMP7 and CHMP4B), and a C-terminal C2 domain enabling membrane lipid binding. CC2D1B is involved in regulating the reformation of the nuclear envelope after mitosis by coordinating timely ESCRT-III recruitment and membrane remodeling, ensuring nuclear integrity following cell division. It also modulates gene transcription, including repression of the serotonin 1A receptor in neurons. Unlike its close homolog CC2D1A, which is linked to intellectual disability and autism, CC2D1B’s deficiency leads to defects in myelination and can impair memory in animal models. There are no known interacting drugs, biomarker uses, or direct links to major human diseases as of current literature.

Other names

KIAA1836LGD1Freud-2lethal (2) giant discs homolog 1Five prime repressor element under dual repression-binding protein 2Lgd1