Coiled-coil domain containing 144 family pseudogene

Coiled-coil domain containing 144 family pseudogene refers to a nonfunctional DNA segment closely related to the coiled-coil domain containing 144 family of genes. Pseudogenes do not produce functional proteins but may retain sequence similarity to functional genes such as CCDC144A[1][5][7]. These are generally categorized as genomic elements without known protein-coding function, regulatory role, or clinical relevance and are not considered therapeutic targets. The identification of such a pseudogene, rather than a protein-coding gene, marks this entry as incorrect for therapeutic targeting, as pseudogenes typically do not participate directly in biological pathways, drug mechanisms, or disease etiology[2][5][7]. Key context and details: - Pseudogene Definition: Pseudogenes are genetically similar to functional genes but lack the ability to encode a functional protein, usually due to disabling mutations or lack of regulatory elements[2][5]. - CCDC144 Family: The CCDC144 gene family includes protein-coding genes such as CCDC144A, as well as multiple related pseudogenes (such as CCDC144CP, CCDC144NL)[1][3][6][7]. - Incorrect Target for Drug Discovery: Since pseudogenes are not transcribed into functional proteins, they are not considered actionable targets in drug discovery or molecular therapeutics[2][5][7]. - Annotation Issues: The use of "coiled-coil domain containing 144 family pseudogene" or ENSG00000250769 does not specify a functional protein or drug target, therefore this entry is considered incorrect or not suitable as a therapeutic target.

Other names

CCDC144 family pseudogeneCCDC144CP (potentially "coiled-coil domain containing 144C, pseudogene"[7][9])CCDC144A (functional family member)CCDC144NL (N-terminal like pseudogene)