Coiled-coil domain containing 53 pseudogene

Coiled-coil domain containing 53 pseudogene (ENSG00000253468) is a genomic region classified as a pseudogene that resembles the functional coiled-coil domain containing 53 gene but does not encode a functional protein product. Pseudogenes, unlike active genes, contain sequence changes such as premature stop codons or frameshifts that prevent normal gene expression and translation, and are therefore generally considered non-functional in terms of protein coding[5]. The parent gene, CCDC53, encodes a protein with a coiled-coil domain—a structural motif found widely in proteins with roles in cell scaffolding, trafficking, and organization[1][2], but such roles do not apply to the pseudogene. Pseudogenes are usually remnants of gene duplication or retrotransposition events and are not considered drug targets, diagnostic markers, nor are they employed in patient selection or safety assessment in therapeutic contexts. - The entry is not a therapeutic target, not a receptor, not an enzyme, and is generally ignored in pharmacology and molecular medicine[2][5]. - The designation as a pseudogene makes it biologically and therapeutically irrelevant for most structured biomedical applications. - The query appears to seek information about a therapeutic target, but ENSG00000253468 is a pseudogene and does not meet the criteria for inclusion as a druggable or functional target.

Other names

ENSG00000253468CCDC53PCGI-116 pseudogene