Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Coiled-coil domain-containing protein 107 (CCDC107)
- Target
- CCDC107
- Molecular classification
- Other (membrane protein, coiled-coil domain-containing protein)
01
Overview
Coiled-coil domain-containing protein 107 is a membrane protein with a central coiled-coil domain, encoded by the CCDC107 gene (HGNC:28465) on human chromosome 9. Several transcript variants exist due to alternative splicing. Its biological function is incompletely characterized but is implicated through transcriptomic and expression studies in cancer, developmental disorders, and as a component of immune and apoptotic pathways. It has served as a biomarker for distinguishing hepatocellular carcinoma and is suggested to be involved as a candidate gene in vascular complications of diabetes. No direct drug interactions, mechanisms of action, or therapeutic applications have been reported for CCDC107.
- Other names
- PSEC0222MGC31967CC107_HUMANCCDC107
02
Mechanism of action
None established for drugs; CCDC107 has not been characterized as a drug target, and no mechanisms of action are defined
03
Biological functions
Potential transcriptional regulation (fusion evidence)Might modulate immune and T cell responses, lysosomal activity, and apoptosis (based on transcriptomics)Protein bindingNuclear localization sequence bindingProtein transporter activityHistone deacetylase bindingPoly(A) RNA binding
04
Disease associations
Cancer (colorectal cancer, hepatocellular carcinoma, see biomarker notes below)Developmental disorders (anauxetic dysplasia 1, cartilage-hair hypoplasia)Cardiovascular disease (DM-related atherogenesis, suggested as a modulator in vascular complications with diabetes)
05
Safety considerations
None specific or notable reported. As it is not a known drug target, therapeutic safety data is lacking. Functional loss may occur in gene fusions, but clinical significance is not established
06
Biomarkers
Differentially expressed in hepatocellular carcinoma—used as part of a gene signature panel for HCC diagnosisExpression changes linked to colorectal cancerPotential biomarker for diabetic vascular complications progression
Beyond the preview
Go deeper on Coiled-coil domain-containing protein 107 (CCDC107).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Coiled-coil domain-containing protein 107 (CCDC107).