Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Coiled-coil domain-containing protein 127 (CCDC127)
- Target
- CCDC127
- Molecular classification
- Other (Coiled-coil domain-containing protein), Protein-coding gene, Not classified as receptor, enzyme, transporter, ion channel, transcription factor, or histone modifier
01
Overview
Coiled-coil domain-containing protein 127 (CCDC127) is a mitochondrial protein encoded by the CCDC127 gene, characterized by its coiled-coil domain structure. It functions as a negative regulator of Hsp70 gene expression and is implicated in cellular stress response, which is relevant to cell survival, drug resistance, and cancer biology. The protein is not a canonical receptor, enzyme, transporter, or transcription factor, but rather a regulatory protein detected in several tissues and cell types, with potential roles in lipid homeostasis and the modulation of stress signaling pathways. Genetic variants and expression changes in CCDC127 have been associated with cancer predisposition but it is not itself a validated therapeutic drug target[1][2][3][4][5].
- Other names
- CCDC127FLJ25701GC05M000258GC05M000204CC127_HUMAN
02
Biological functions
Negative regulation of Hsp70 gene expression (stress response)Putative involvement in lipid homeostasisModulation of stress signaling pathways (potential impact on cell survival and drug resistance)
03
Disease associations
Cancer (including inherited cancer-predisposing syndrome, spindle cell liposarcoma)Potential roles in other diseases via gene expression association, but specific mechanisms are not established
Beyond the preview
Go deeper on Coiled-coil domain-containing protein 127 (CCDC127).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Coiled-coil domain-containing protein 127 (CCDC127).