Coiled-coil domain-containing protein 142 (CCDC142)

Coiled-coil domain-containing protein 142 (CCDC142) is a human protein encoded by the CCDC142 gene located on chromosome 2p13.1 and comprises 743 or 665 amino acids, depending on the isoform[1][7]. The protein features a large coiled-coil domain (amino acids 308–719) and a RINT1_TIP1 motif (amino acids 490–621), but its precise biological function is unknown[1]. Expression is observed at low levels in several regions of the human brain and in peripheral tissues like the mouth and thymus[1]. Although CCDC142 is conserved across many animal species, there are currently no known protein interaction partners or roles as a receptor, enzyme, or recognized cellular target, nor are there drugs that target it directly. Genetic alterations including copy number variation encompassing CCDC142 may coincide with various developmental syndromes, but there is no evidence that CCDC142 itself is directly actionable or pathogenic in these diseases[1][7][9].

Other names

CCDC142PSEC0243FLJ14397Coiled-coil domain containing 142

Not established; no drugs reported to target this molecule