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Target intelligence / Profile preview
Coiled-coil domain-containing protein 167 (CCDC167)
- Target
- CCDC167
- Molecular classification
- Other
01
Overview
Coiled-coil domain-containing protein 167 (CCDC167) is a membrane-associated protein upregulated in various cancers, most notably breast cancer, where high expression correlates with poor prognosis. CCDC167 is involved in cell cycle progression, ubiquitination, mitosis, and is regulated by multiple oncogenic networks. Knockdown or inhibition of CCDC167 suppresses cancer cell proliferation and tumor progression, suggesting CCDC167 as a candidate therapeutic target and a negative prognostic marker in breast cancer. The gene is affected by common chemotherapeutic agents, highlighting its potential as a biomarker and modulator of drug response in oncology.
- Other names
- CCDC167C6orf129HSPC265dJ153P14.2coiled-coil domain containing 167coiled-coil domain-containing protein 167transmembrane and coiled-coil domain-containing protein C6orf129
02
Mechanism of action
Downregulation of CCDC167 by cytotoxic and chemotherapeutic agents suppresses cancer cell proliferation and tumor progression
03
Biological functions
Cell proliferationCell cycle regulationApoptosisUbiquitinationSignal transductionImmune response
04
Disease associations
Cancer, specifically breast cancer
05
Safety considerations
No specific CCDC167-targeted drugs or safety concerns reported to date; information is based on modulation by standard chemotherapeutics
06
Interacting drugs
Fluorouracil
3 more in the full profile.
07
Biomarkers
High CCDC167 expression as a prognostic indicator of poor outcome in breast cancerpotential target for response to cytotoxic chemotherapy
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