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Coiled-coil domain-containing protein 17 (CCDC17)
- Target
- CCDC17
- Molecular classification
- Other (Coiled-coil domain-containing protein)
01
Overview
Coiled-coil domain-containing protein 17 (CCDC17) is a human protein encoded by the CCDC17 gene (NCBI Gene ID: 149483; UniProtKB: Q96LX7) characterized by multiple coiled-coil domains[5]. Immunostaining studies demonstrate that CCDC17 localizes to both the tip and basal body regions of cilia, suggesting a putative role in ciliary structure or function; however, its precise biological function is not well-defined[2]. Recent epigenetic analyses have revealed hypermethylation of CCDC17 in keratoacanthoma samples, implicating altered gene regulation in this self-limiting epidermal tumor, and there is some connection to colorectal adenocarcinoma, though mechanistic details remain unclear[4]. Overall, CCDC17 is not currently recognized as a therapeutic target, nor are there known drugs, biomarkers, or safety risks associated with its modulation. It is primarily classified as a structural protein with possible involvement in organelle architecture, typical of coiled-coil domain proteins[1][2][3][4][5].
- Other names
- FLJ33084coiled-coil domain containing 17coiled-coil domain-containing protein 17CCDC17
02
Mechanism of action
None reported. No targeted therapeutics or mechanism defined for drug-targeting CCDC17
03
Biological functions
Probable involvement in ciliary biology, specifically localizing to the ciliary tip and basal body regions.Potential role in cellular architecture and organelle positioning, typical of coiled-coil proteins, but precise functions remain undefined.May be involved in protein-protein interactions or act as a molecular scaffold or spacer
04
Disease associations
Other: Implicated in epigenetic changes associated with keratoacanthoma (a self-limiting epidermal tumor).Other: Indirect association with colorectal adenocarcinoma, though specific disease mechanisms are unclear
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