Target intelligence / Profile preview

Coiled-coil domain-containing protein 171 (CCDC171)

Target
CCDC171
Molecular classification
Other (coiled-coil domain-containing protein, protein-coding gene), Not classified as a receptor, enzyme, ion channel, transporter, or transcription factor in current annotations
01

Overview

Coiled-coil domain-containing protein 171 (CCDC171) is a human protein encoded by the CCDC171 gene (also described as myosin tail domain containing protein based on sequence features). CCDC171 is a member of the coiled-coil domain-containing protein family, a broad group of proteins defined by the presence of a coiled-coil structural motif, which is frequently involved in protein-protein interactions. CCDC171 itself is annotated as a protein-coding gene; its biological function is not well characterized. Some gene ontology annotations suggest possible DNA-binding transcription factor activity, but this is not experimentally validated. There is minimal evidence for significant biological functions, disease roles, or therapeutic targeting; CCDC171 is not classified as a receptor, enzyme, transporter, or drug target. Some cancer fusion events involving CCDC171 (such as CCDC171-CNTLN) have been observed, but their biological impact remains poorly defined, and CCDC171 is not implicated as a driver gene in human pathology. As of now, CCDC171 should be considered a poorly characterized structural protein with limited annotation for molecular, biological, or clinical functions[1][3][4][5][9][10].

Other names
C9orf93FLJ39267FLJ46740bA778P13.1bA536D16.1myosin tail domain containing proteincoiled-coil domain containing 171coiled-coil domain-containing protein 171
02

Mechanism of action

None known. No drugs targeting CCDC171 have described mechanisms of action

03

Biological functions

DNA-binding transcription factor activity (annotation, not experimental proof)Required for centrosome cohesion and recruitment of CEP68 to centrosomes (inferred from functional studies for fusion gene partners in cell cycle contexts)None of these are confirmed as major, canonical biological functions for CCDC171 individually.
04

Disease associations

Cancer (CCDC171 gene fusions, e.g., CCDC171-CNTLN, have been observed in tumor samples, e.g. colon adenocarcinoma/COAD and have minor pan-cancer fusion scores)Prostate cancer (associated per gene-disease annotation, but not well-characterized as causative)Distal myopathy (associated per gene-disease annotation, but not well-characterized as causative)No strong evidence for direct disease causality; limited disease linkage.
05

Safety considerations

None reported. There are no therapeutic applications or safety concerns documented for this molecule

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