Coiled-coil domain-containing protein 172 (CCDC172)

Coiled-coil domain-containing protein 172 (CCDC172) is a protein encoded by the CCDC172 gene, also known as TEKT2-binding protein 1 (TEKT2BP1) and C10orf96[1][3][7]. This protein contains a characteristic coiled-coil domain, predicting a structural or scaffolding cellular role[1][3][6]. CCDC172 is most prominently expressed in testis, especially localized at the mitochondria sheath in the middle piece of sperm flagella in rodents, where it is implicated in the organization or linkage between outer dense fibers (ODF) and mitochondria, supporting normal flagellar structure and function[1][3]. Protein interaction data indicate roles as a protein-macromolecule adaptor and as a structural cytoskeleton constituent[5]. There is currently no strong evidence to support a role for CCDC172 as a conventional therapeutic target (e.g., receptor, enzyme, transporter) or as a biomarker or drug-interacting molecule. Human genetic databases annotate possible associations with several heritable diseases, but specific direct pathological or pharmacological roles remain uncharacterized[7]. Summary: - Coiled-coil domain-containing protein 172 (CCDC172) is a structural protein with key expression in testis and a possible function in sperm flagellum organization, but there is no current evidence supporting it as a drug target, receptor, or biomarker. There are no established interacting drugs, mechanisms of action, or safety concerns documented in the literature[1][3][5][6][7].

Other names

C10orf96TEKT2-binding protein 1TEKT2BP1MGC35062UPF0628 protein C10orf96