Coiled-coil domain-containing protein 177 (CCDC177)

Coiled-coil domain-containing protein 177 (CCDC177) is a human protein encoded by the CCDC177 gene located on chromosome 14q24.1[2][3]. The protein consists of 707 amino acids and contains a coiled-coil domain that overlaps with a domain of unknown function (DUF4659)[2][1]. CCDC177 is ubiquitously expressed in adult tissues but is less abundant in fetal tissues and immune cells[2]. It localizes primarily to the nucleus, but also shuttles between nucleus and cytosol, regulated by nuclear localization/export signals and phosphorylation[2]. CCDC177 interacts with proteins involved in neuronal growth, development, and cell cycle regulation, including MYCBP2, FOXN4, HDAC5, and TAL1[2]. Functionally, it is implicated in developmental processes and cell survival signaling, but precise molecular functions remain unclear[2]. Clinically, CCDC177 deletions are associated with mild intellectual disability and congenital heart defects. Differential methylation or expression of the CCDC177 gene is correlated with prognosis and/or survival in neuroblastoma, thyroid cancer, and lung squamous cell carcinoma[2]. CCDC177 is not a well-validated therapeutic target based on current evidence—it is primarily of interest as a biomarker and in basic developmental biology. Despite the "myelin proteolipid protein-like protein" alias, the CCDC177 protein is distinct from the canonical Myelin proteolipid protein (PLP1 gene), which is a critical myelin structural protein and a validated target in demyelinating diseases[4]. CCDC177 does not encode PLP1 and should not be conflated with it; evidence for myelination-specific function is lacking for CCDC177[2][4]. No known drugs or therapeutic agents are documented to interact with CCDC177 as of current knowledge[2][3].

Other names

C14orf162PLPLMyelin proteolipid protein-like proteincoiled-coil domain containing 177