Coiled-coil domain-containing protein 18 (CCDC18)

Coiled-coil domain-containing protein 18 (CCDC18) is a human protein encoded by the *CCDC18* gene, located on chromosome 1p22.1 and consisting of 33 exons[2][6]. The protein contains a coiled-coil domain, which is a structural motif typically found in proteins involved in scaffolding, molecular spacing, and protein-protein interactions[1][3]. CCDC18 is specifically localized to the centriolar satellite, suggesting a role in centrosome or microtubule organization[2][6]. The gene has a documented association with sarcoma, as reflected by its alternative names that include NY-SAR-41 and Sarcoma antigen NY-SAR-24[6]. Its known molecular function includes possible nucleotide binding, but no direct evidence supports enzymatic activity or classification as a receptor, transporter, or traditional drug target[6]. No known drugs targeting CCDC18 or established mechanisms of action for therapeutic manipulation of this protein have been reported, nor is it currently used as a biomarker or associated with specific safety concerns in therapy[6][2]. Its primary biological significance is structural, typical for coiled-coil domain proteins, and it may play a supporting role in cell division or centriolar function, based on the functional principles of this protein family[1][6].

Other names

NY-SAR-41Sarcoma antigen NY-SAR-24Sarcoma antigen NY-SAR-41