Coiled-coil domain-containing protein 180 (CCDC180)

Coiled-coil domain-containing protein 180 (CCDC180) is a nuclear-localized protein comprising 1,701 amino acids, encoded by the *CCDC180* gene on human chromosome 9q22.33. It contains two overlapping coiled-coil regions and two domains of unknown function (DUF4455 and DUF4456). CCDC180 is predominately expressed in testes, with lower expression seen in other tissues including trachea and eye. Its transcription is regulated by multiple factors, notably SRY and SOX transcription factors, hinting at a role in sex determination and possibly transcription regulation. CCDC180 interacts with several cell cycle and signaling proteins such as Y box binding protein 1, Erb-B2 receptor tyrosine kinase 2, and retinoblastoma 1. Although a SNP (S995C) in CCDC180 is linked to Behçet's disease, its precise pathogenic mechanism remains unknown. There is no evidence to date for direct drug targeting, or identification of approved/well-studied inhibitors, agonists, or modulators.

Other names

KIAA1529BDAG1C9orf174DKFZp434I2420FAP76CFAP76

Not applicable (no therapeutics target this protein)